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245	0	4	_aThe aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution / _cLuis Ríos, Meg M. Sleeper, Marietta D. Danforth, Hayley Weston Murphy, Ilana Kutinsky, Antonio Rosas, Markus Bastir, José Gómez-Cambronero, Ricardo Sanjurjo, Laurence Campens, Oliver Rider, Francisco Pastor.
260			_a[S.l.]: _bScientific Reports, _c2023.
336			_atexto (visual)
337			_3en línea _aelectrónico
520			_aHumans have a larger energy budget than great apes, allowing the combination of the metabolically expensive traits that define our life history. This budget is ultimately related to the cardiac output, the product of the blood pumped from the ventricle and the number of heart beats per minute, a measure of the blood available for the whole organism physiological activity. To show the relationship between cardiac output and energy expenditure in hominid evolution, we study a surrogate measure of cardiac output, the aortic root diameter, in humans and great apes. When compared to gorillas and chimpanzees, humans present an increased body mass adjusted aortic root diameter. We also use data from the literature to show that over the human lifespan, cardiac output and total energy expenditure follow almost identical trajectories, with a marked increase during the period of brain growth, and a plateau during most of the adult life. The limited variation of adjusted cardiac output with sex, age and physical activity supports the compensation model of energy expenditure in humans. Finally, we present a first study of cardiac output in the skeleton through the study of the aortic impression in the vertebral bodies of the spine. It is absent in great apes, and present in humans and Neanderthals, large-brained hominins with an extended life cycle. An increased adjusted cardiac output, underlying higher total energy expenditure, would have been a key process in human evolution.
524			_aRíos, L, Sleeper, M.M., Danforth, M.D., Murphy, H.W., Kutinsky, I., Rosas, A., Bastir, M., Gómez-Cambronero, J., Sanjurjo, R., Campens, L., Rider, O., Pastor, F., 2023. The aorta in humans and African great apes, and cardiac output and metabolic levels in human evolution. Sci. Rep. 13, 6841. https://doi.org/10.1038/s41598-023-33675-1
591			_aANTROPOLOGIAFISICA
592			_aANTROPOLOGIAFISICA
700	1		_913079 _aRios Frutos, Luis _d1975-
700	1		_aSleeper, Meg M. _91442335
700			_aDanforth, Marietta D. _91442336
700	1		_aMurphy, Hayley Weston _91442338
700	1		_91442337 _aKutinsky, Ilana
700	1		_91433255 _aRosas, Antonio
700	1		_91134460 _aBastir, Markus
700	1		_aGómez-Cambronero, José _91442339
700	1		_aSanjurjo, Ricardo _91442340
700	1		_aCampens, Laurence _91442341
700			_a Oliver Rider, _91442342
700	1		_aPastor, Francisco _9615881
710	2		_aAranzadi Zientzia Elkartea _91442343
856			_uhttps://www.nature.com/articles/s41598-023-33675-1
942			_2cdu _cPUBL